One day while Prophet Muhammad (ﷺ) was in his last days, his only child still alive, Fatimah (رَضِيَ ٱللَّٰهُ عَنْهَا) came to visit. He told her privately that Angel Gabriel used to review the Qur’an with him once each year, and this time, he reviewed it twice. Prophet Muhammad told his daughter that he believes it means that his time has arrived. He also told her that she will be the first of his family to catch up with him. [Source: Sahih Bukhari 3623]

As one scholar explained, there is two prophecies in what the Prophet said: one regarding his death and one regarding daughter’s death. Prophet Muhammad, like anyone, had multiple sicknesses in his life, and they were intense in nature. Yet, there’s no report of him saying he would pass away in any of them. This was the only time he did and that’s what happened.

With his daughter, there are several interesting factors to keep in mind. For one, she was only in her 20’s. For one to predict an upcoming death for someone that young is bold in itself. As well, Prophet Muhammad had a lot of other family members of various ages. Predicting Fatimah to be first to pass away amongst all of them says a lot. Yet, that’s what also happened. Within a few months after Prophet Muhammad (ﷺ) passed away, Fatimah too fell ill and passed away.